Study participant Sean O’Connell is given a shot in this undated handout photo. Canadian researchers have launched a study to determine if a century-old vaccine against tuberculosis can offer some protection against COVID-19. Investigators at the University Health Network in Toronto say they hope to test a theory that Bacille Calmette Guerin, or BCG, can reduce the incidence and severity of COVID-19 infection. THE CANADIAN PRESS/HO - University Health Network

Canadian researchers explore whether TB vaccine offers COVID-19 protection

The trial is open to police, fire and health-care workers who are at greater risk of COVID-19 exposure

Canadian researchers have launched a study to determine if a century-old vaccine against tuberculosis can offer some protection against COVID-19.

Investigators at the University Health Network in Toronto say they hope to test a theory that Bacille Calmette Guerin, or BCG, can reduce the incidence and severity of COVID-19 infection.

The trial is open to police, fire and health-care workers who are at greater risk of COVID-19 exposure, with researchers hoping to recruit more than 3,600 participants.

Principal co-investigator Dr. Alexandre Zlotta says that if the inexpensive vaccine proves helpful, it can be rapidly deployed to offer temporary protection until a COVID-specific vaccine is widely available.

While BCG continues to be used in European and developing countries, Canada discontinued routine use in the early 1970s, according to Toronto Public Health.

Tuberculosis cases in Canada are among the lowest in the world, although certain vulnerable populations are at higher risk for the infectious, bacterial disease.

Dubbed “COBRA,” the double-blind placebo-controlled study is unfolding alongside trials in Germany and the United States. Experts expect to release results in May 2021.

Interest in BCG emerged early in the pandemic when researchers noticed some countries with higher rates of BCG coverage also had significantly lower rates of COVID-19 deaths. But more recent analysis reflecting the pandemic’s movement across the globe bucks that idea.

“Lack of evidence for BCG vaccine protection from severe COVID-19,” states the headline of a letter published in the Proceedings of the National Academy of Sciences on Sept. 29.

Citing updated analysis based on data from the Johns Hopkins University Coronavirus Resource Center, the study notes Bolivia, Panama, Columbia, Peru, Brazil, Mexico and South Africa had the largest increases in COVID-19 deaths on Aug. 1, even though the countries also have high BCG coverage.

The letter concludes by saying ongoing randomized controlled trials should provide more concrete answers.

UHN says the Canadian study uses an improved version of the vaccine, which researchers expect “will help muster a stronger immune response.”

“The big advantage here is this vaccine has been given to billions of people around the world in the past decades,” Zlotta says in a release.

“It is safe and readily available. If the study is successful, this could become an important strategy to control the secondary waves of the pandemic.”

The study is being funded by The Princess Margaret Cancer Foundation.

Cassandra Szklarski, The Canadian Press


Like us on Facebook and follow us on Twitter.

Want to support local journalism during the pandemic? Make a donation here.

Coronavirusvaccines

Get local stories you won't find anywhere else right to your inbox.
Sign up here

Just Posted

(Photo Submitted by the Gord Bamford Foundation)
Lacombe’s Gord Bamford to perform a virtual concert for a good cause

The concert aims to raise awareness for Operation Santa Clause

Alberta Health Services' central zone jumped from 162 active COVID-19 cases to 178 on Friday. Five additional deaths were reported provincewide, bringing the toll to 323. THE CANADIAN PRESS/Graham Hughes
622 new COVID-19 cases set another daily high Friday

Province confirmed 622 additional cases Friday

best
Heartland Stationer’s lands ‘Stettler’s Best Kept Secret’ award through the Stettler Board of Trade

Successful long-time business will be starting a new chapter with a name change and relocation

lights
Mark your calendars for the annual ‘Festival of Lights’ holiday events

Annual celebration raises funds in support of patient care at the Stettler Hospital

Over the years, Janice Blackie-Goodine’s home in Summerland has featured elaborate Halloween displays and decorations each October. (File photo)
QUIZ: How much do you really know about Halloween?

Oct. 31 is a night of frights. How much do you know about Halloween customs and traditions?

(Photo submitted)
Rimbey resident avid author despite Parkinson’s

Wins more accolades for her writing

(Photo Submitted by the Gord Bamford Foundation)
Lacombe’s Gord Bamford to perform a virtual concert for a good cause

The concert aims to raise awareness for Operation Santa Clause

City of Wetaskiwin Mayor presenting the AUMA Above & Beyond Award to John Maude and Susan Quinn. Ren Goode/ City of Wetaskiwin.
Wetaskiwin County residents win the AUMA Above & Beyond Award

John Maude and Susan Quinn are being recognized for their role in Wetaskiwin’s sustainability.

Conservative leader Erin O’Toole rises during Question Period in the House of Commons in Ottawa on Wednesday October 28, 2020. (Adrian Wyld/The Canadian Press)
Conversion therapy ban gets approval in principle, exposes Conservative divisions

Erin O’Toole himself voted in favour of the bill, as did most Conservative MPs

Pilots Ilona Carter and Jim Gray of iRecover Treatment Centres, in front of his company’s aircraft, based at Ponoka’s airport. (Perry Wilson/Submitted)
95-year-old Ilona Carter flies again

Takes to the skies over Ponoka

Children’s backpacks and shoes are seen at a daycare in Langley, B.C., on Tuesday May 29, 2018. Alberta Children’s Services Minister Rebecca Schulz says the province plans to bring in a new way of licensing and monitoring child-care facilities. THE CANADIAN PRESS/Darryl Dyck
Alberta proposes legislation to change rules on child-care spaces

Record-keeping, traditionally done on paper, would be allowed digitally

Prime Minister Justin Trudeau shakes hands with US Vice-President Joe Biden on Parliament Hill in Ottawa on Friday, December 9, 2016. THE CANADIAN PRESS/ Patrick Doyle
A Biden presidency could mean good news for Canadian environment policy: observers

Experts and observers say even a U.S. outside the Paris agreement may ultimately end up in the same place

People take a photo together during the opening night of Christmas Lights Across Canada, in Ottawa, on Wednesday, Dec. 4, 2019. The likelihood that most Canadians will enjoy a holly jolly Christmas season of gatherings, caroling and travel is unlikely, say public health experts who encourage those who revel in holiday traditions to accept more sacrifices ahead. THE CANADIAN PRESS/Justin Tang
Ho, ho, no: Experts advise preparing for a scaled-back COVID holiday season

Many of the holiday season’s highlights have already been scrapped or are unlikely to take place

Most Read